{"id":560,"date":"2024-04-04T18:02:20","date_gmt":"2024-04-04T16:02:20","guid":{"rendered":"https:\/\/us.biomaterials-bioengineering.com\/?page_id=560"},"modified":"2025-08-04T12:09:48","modified_gmt":"2025-08-04T10:09:48","slug":"job-offers","status":"publish","type":"page","link":"https:\/\/us.biomaterials-bioengineering.com\/index.php\/job-offers\/","title":{"rendered":"JOB OFFERS"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"560\" class=\"elementor elementor-560\">\n\t\t\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-d29b050 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"d29b050\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-faf5e22\" data-id=\"faf5e22\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-15f8833 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"15f8833\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-03a930d\" data-id=\"03a930d\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e4aad63 elementor-widget-divider--separator-type-pattern elementor-widget-divider--no-spacing elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"e4aad63\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.14.0 - 26-06-2023 *\/\n.elementor-widget-divider{--divider-border-style:none;--divider-border-width:1px;--divider-color:#0c0d0e;--divider-icon-size:20px;--divider-element-spacing:10px;--divider-pattern-height:24px;--divider-pattern-size:20px;--divider-pattern-url:none;--divider-pattern-repeat:repeat-x}.elementor-widget-divider .elementor-divider{display:flex}.elementor-widget-divider .elementor-divider__text{font-size:15px;line-height:1;max-width:95%}.elementor-widget-divider .elementor-divider__element{margin:0 var(--divider-element-spacing);flex-shrink:0}.elementor-widget-divider .elementor-icon{font-size:var(--divider-icon-size)}.elementor-widget-divider .elementor-divider-separator{display:flex;margin:0;direction:ltr}.elementor-widget-divider--view-line_icon .elementor-divider-separator,.elementor-widget-divider--view-line_text .elementor-divider-separator{align-items:center}.elementor-widget-divider--view-line_icon .elementor-divider-separator:after,.elementor-widget-divider--view-line_icon .elementor-divider-separator:before,.elementor-widget-divider--view-line_text .elementor-divider-separator:after,.elementor-widget-divider--view-line_text .elementor-divider-separator:before{display:block;content:\"\";border-bottom:0;flex-grow:1;border-top:var(--divider-border-width) var(--divider-border-style) var(--divider-color)}.elementor-widget-divider--element-align-left .elementor-divider .elementor-divider-separator>.elementor-divider__svg:first-of-type{flex-grow:0;flex-shrink:100}.elementor-widget-divider--element-align-left .elementor-divider-separator:before{content:none}.elementor-widget-divider--element-align-left .elementor-divider__element{margin-left:0}.elementor-widget-divider--element-align-right .elementor-divider .elementor-divider-separator>.elementor-divider__svg:last-of-type{flex-grow:0;flex-shrink:100}.elementor-widget-divider--element-align-right .elementor-divider-separator:after{content:none}.elementor-widget-divider--element-align-right .elementor-divider__element{margin-right:0}.elementor-widget-divider:not(.elementor-widget-divider--view-line_text):not(.elementor-widget-divider--view-line_icon) .elementor-divider-separator{border-top:var(--divider-border-width) var(--divider-border-style) var(--divider-color)}.elementor-widget-divider--separator-type-pattern{--divider-border-style:none}.elementor-widget-divider--separator-type-pattern.elementor-widget-divider--view-line .elementor-divider-separator,.elementor-widget-divider--separator-type-pattern:not(.elementor-widget-divider--view-line) .elementor-divider-separator:after,.elementor-widget-divider--separator-type-pattern:not(.elementor-widget-divider--view-line) .elementor-divider-separator:before,.elementor-widget-divider--separator-type-pattern:not([class*=elementor-widget-divider--view]) .elementor-divider-separator{width:100%;min-height:var(--divider-pattern-height);-webkit-mask-size:var(--divider-pattern-size) 100%;mask-size:var(--divider-pattern-size) 100%;-webkit-mask-repeat:var(--divider-pattern-repeat);mask-repeat:var(--divider-pattern-repeat);background-color:var(--divider-color);-webkit-mask-image:var(--divider-pattern-url);mask-image:var(--divider-pattern-url)}.elementor-widget-divider--no-spacing{--divider-pattern-size:auto}.elementor-widget-divider--bg-round{--divider-pattern-repeat:round}.rtl .elementor-widget-divider .elementor-divider__text{direction:rtl}.e-con-inner>.elementor-widget-divider,.e-con>.elementor-widget-divider{width:var(--container-widget-width,100%);--flex-grow:var(--container-widget-flex-grow)}<\/style>\t\t<div class=\"elementor-divider\" style=\"--divider-pattern-url: url(&quot;data:image\/svg+xml,%3Csvg xmlns=&#039;http:\/\/www.w3.org\/2000\/svg&#039; preserveAspectRatio=&#039;none&#039; overflow=&#039;visible&#039; height=&#039;100%&#039; viewBox=&#039;0 0 24 24&#039; fill=&#039;black&#039; stroke=&#039;none&#039;%3E%3Cpath d=&#039;M24,8v12H0V8H24z M24,4v1H0V4H24z&#039;\/%3E%3C\/svg%3E&quot;);\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c650740 elementor-widget elementor-widget-heading\" data-id=\"c650740\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.14.0 - 26-06-2023 *\/\n.elementor-heading-title{padding:0;margin:0;line-height:1}.elementor-widget-heading .elementor-heading-title[class*=elementor-size-]>a{color:inherit;font-size:inherit;line-height:inherit}.elementor-widget-heading .elementor-heading-title.elementor-size-small{font-size:15px}.elementor-widget-heading .elementor-heading-title.elementor-size-medium{font-size:19px}.elementor-widget-heading .elementor-heading-title.elementor-size-large{font-size:29px}.elementor-widget-heading .elementor-heading-title.elementor-size-xl{font-size:39px}.elementor-widget-heading .elementor-heading-title.elementor-size-xxl{font-size:59px}<\/style><h2 class=\"elementor-heading-title elementor-size-default\">JOB OFFERS<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-35c4430 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"35c4430\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3cab5fe elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3cab5fe\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-6d2dc73\" data-id=\"6d2dc73\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c8f7af5 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c8f7af5\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-bca382c\" data-id=\"bca382c\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-dd03a01 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"dd03a01\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-91c0765\" data-id=\"91c0765\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-bbad793 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"bbad793\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-de1e7b3\" data-id=\"de1e7b3\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a228b15 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"a228b15\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f050ffd elementor-widget elementor-widget-image\" data-id=\"f050ffd\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.14.0 - 26-06-2023 *\/\n.elementor-widget-image{text-align:center}.elementor-widget-image a{display:inline-block}.elementor-widget-image a img[src$=\".svg\"]{width:48px}.elementor-widget-image img{vertical-align:middle;display:inline-block}<\/style>\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"126\" src=\"https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-stage-master-300x126.png\" class=\"attachment-medium size-medium wp-image-939\" alt=\"\" srcset=\"https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-stage-master-300x126.png 300w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-stage-master-1024x430.png 1024w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-stage-master-768x322.png 768w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-stage-master-1536x645.png 1536w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-stage-master-2048x860.png 2048w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-stage-master-238x100.png 238w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-stage-master-191x80.png 191w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-stage-master-394x165.png 394w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-stage-master-915x384.png 915w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-stage-master-1240x521.png 1240w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-stage-master-1920x806.png 1920w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9e27737 elementor-widget elementor-widget-heading\" data-id=\"9e27737\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Polymer Nanoparticles loaded with Au Nanoclusters for NIR-II Bioimaging<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d905fc1 elementor-widget elementor-widget-text-editor\" data-id=\"d905fc1\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<style>\/*! elementor - v3.14.0 - 26-06-2023 *\/\n.elementor-widget-text-editor.elementor-drop-cap-view-stacked .elementor-drop-cap{background-color:#69727d;color:#fff}.elementor-widget-text-editor.elementor-drop-cap-view-framed .elementor-drop-cap{color:#69727d;border:3px solid;background-color:transparent}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap{margin-top:8px}.elementor-widget-text-editor:not(.elementor-drop-cap-view-default) .elementor-drop-cap-letter{width:1em;height:1em}.elementor-widget-text-editor .elementor-drop-cap{float:left;text-align:center;line-height:1;font-size:50px}.elementor-widget-text-editor .elementor-drop-cap-letter{display:inline-block}<\/style>\t\t\t\t<p>Luminescence and fluorescence have the potential to achieve fast and sensitive biosensing and bioimaging with resolutions down to single biomolecules, but they require powerful and specific probes. Luminescent polymer nanoparticles (NPs) are rapidly gaining importance as bright probes.<sup>[1,2]<\/sup> At the same time, the strong autofluorescence, absorption, and scattering of cells and tissues still strongly limit the achievable resolutions at depths beyond the \u00b5m-scale.<sup>[3]<\/sup> A solution to overcome these problems is shifting the observation wavelengths to the second near infrared window (NIR-II) between 1000 and 1700 nm. However, bright contrast agents emitting in this wavelength region remain scarce.<\/p><p>In the present project, we will <strong>design a new type of luminescent nanohybrid by encapsulating high amounts of NIR-II emitting gold nanoclusters in polymer NPs.<\/strong><sup>[4\u20136]<\/sup> The intern will work on polymer synthesis, nanoparticle formulation through nanoprecipitation, and their characterization (dynamic light scattering, electron microscopy and fluorescence spectroscopy). The resulting new class of nanohybrid based contrast agents will be evaluated within a project involving three partner laboratories for in depth bioimaging at the single particle level in the context of early detection of fibrosis.<\/p><p><strong>We are looking for a motivated master student who is interested in working at the interface of polymer science, material science, and bioimaging<\/strong>. The proposed M2 internship is part of an ambitious ANR project including specialists in material and polymer science, photophysics and biology. The internship will take place in the Laboratory of Biomat\u00e9riaux et Bioing\u00e9nierie at the CRBS, Strasbourg, under the supervision of Andreas Reisch. Our lab offers a strongly interdisciplinary and international environment with researchers from biology, chemistry, and physics. It features up-to date chemical synthesis facilities and equipment for material characterization, fluorescence imaging, and cell culture.<\/p><p><strong>To apply<\/strong>, please contact Andreas Reisch (reisch@unistra.fr) joining a brief CV, recent grades, and a motivation letter.<\/p><p>\u00a0<\/p><p><u>References<\/u><\/p><ol><li>X. Han, K. Xu, O. Taratula, K. Farsad, <em>Nanoscale<\/em> <strong>2019<\/strong>, <em>11<\/em>, 799.<\/li><li>A. H. Ashoka, I. O. Aparin, A. Reisch, A. S. Klymchenko, <em>Chem. Soc. <\/em><em>Rev.<\/em> <strong>2023<\/strong>, 2023,<strong>52<\/strong>, 4525-4548.<\/li><li>S. Yoon <em>et al.<\/em>, <em>Nat Rev Phys<\/em> <strong>2020<\/strong>, <em>2<\/em>, 141.<\/li><li>X. L. Gu\u00e9vel <em>et al.<\/em>, <em>Chem. <\/em><em>Commun.<\/em> <strong>2022<\/strong>, <em>58<\/em>, 2967.<\/li><li>L. Haye <em>et al.<\/em>, <em>Advanced Optical Materials<\/em> <strong>2023<\/strong>, <em>11<\/em>, 2201474.<\/li><li>A. A. Simon <em>et al.<\/em>, <em>Advanced Science<\/em> <strong>2024<\/strong>, <em>11<\/em>, 2309267.<\/li><\/ol>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6051351 elementor-widget elementor-widget-image\" data-id=\"6051351\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"448\" height=\"145\" src=\"https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Image-stage-master-andreas.png\" class=\"attachment-large size-large wp-image-951\" alt=\"\" srcset=\"https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Image-stage-master-andreas.png 448w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Image-stage-master-andreas-300x97.png 300w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Image-stage-master-andreas-309x100.png 309w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Image-stage-master-andreas-247x80.png 247w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Image-stage-master-andreas-394x128.png 394w\" sizes=\"auto, (max-width: 448px) 100vw, 448px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4334ff1 elementor-widget__width-initial elementor-widget elementor-widget-text-editor\" data-id=\"4334ff1\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p style=\"text-align: center;\"><em>Scheme of Assembly of luminescent nanoparticles and their use in single particletracking<\/em><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ff666ac elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"ff666ac\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-94a63db elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"94a63db\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8184537\" data-id=\"8184537\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3fc8d2c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3fc8d2c\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-cfb0d06\" data-id=\"cfb0d06\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-002e836 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"002e836\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9cb864f elementor-widget elementor-widget-image\" data-id=\"9cb864f\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"126\" src=\"https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-stage-master-300x126.png\" class=\"attachment-medium size-medium wp-image-939\" alt=\"\" srcset=\"https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-stage-master-300x126.png 300w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-stage-master-1024x430.png 1024w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-stage-master-768x322.png 768w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-stage-master-1536x645.png 1536w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-stage-master-2048x860.png 2048w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-stage-master-238x100.png 238w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-stage-master-191x80.png 191w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-stage-master-394x165.png 394w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-stage-master-915x384.png 915w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-stage-master-1240x521.png 1240w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-stage-master-1920x806.png 1920w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-efc9551 elementor-widget elementor-widget-heading\" data-id=\"efc9551\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Protein Based Compact Biomaterials and Bioplastics<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-34abc01 elementor-widget elementor-widget-text-editor\" data-id=\"34abc01\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>Protein-based materials are among nature\u2019s most performant materials ranging from slimes over tendons to spider silk. As natural dervied and biodegradable materials they are also strongly researched as a new class of man-made materials. Recently a new mechanical resistant, <strong>compact albumin-based material<\/strong> was produced in our lab using a mild, non-denaturing process (no chemical crosslinking agents, no solvents, mild pH, low temperature).<sup>[1]<\/sup> Such materials have many potential biomedical applications ranging from devices for controlled release of drugs to structural biomaterials and even bioplastics.<sup>[2,3]<\/sup><\/p><p>Within the present project, we aim at deepening our <strong>understanding of such compact protein materials<\/strong> and extending them to <strong>incorporation of various proteins and natural polymers<\/strong>. Targeted modification of the surface functional groups will be used to study the relation between protein chemistry and materials properties, using microscopy and mechanical evaluation The obtained results will be the basis to generalize our approach to different classes of proteins and polysaccharides like chitosan.<sup>[4]<\/sup> In this way, and based on recent advances in polyelectrolyte materials,<sup>[5,6]<\/sup> a family of entirely bio-based materials with tailored mechanical properties will be generated.<\/p><p>We are looking for a motivated master student who is interested in working at the interface of polymer \/materials science, formulation of biomaterials, their biological evaluation, and physical-chemical characterization.<\/p><p>The internship will take place in the Laboratory of <strong>Biomat\u00e9riaux &amp; Bioing\u00e9nierie<\/strong> under the supervision of Andreas Reisch. Our lab offers a strongly interdisciplinary and international environment with researchers from biology, chemistry, and physics. It features up-to date chemical synthesis facilities and equipment for material characterization, fluorescence imaging, and cell culture. <\/p><p>\u00a0<\/p><p><strong>To apply<\/strong>, please contact Andreas Reisch (reisch@unistra.fr) joining a brief CV, recent grades, and a motivation letter.<\/p><p>\u00a0<\/p><p><u>References<\/u><\/p><ol><li>E. Aloui <em>et al.<\/em>, <em>Advanced Healthcare Materials<\/em> <strong>2025<\/strong>, <em>14<\/em>, 2403385.<\/li><li>L. P. Datta, S. Manchineella, T. Govindaraju, <em>Biomaterials<\/em> <strong>2020<\/strong>, <em>230<\/em>, 119633.<\/li><li>D. Miranda-Nieves, E. L. Chaikof, <em>ACS Biomater. Sci. Eng.<\/em> <strong>2017<\/strong>, <em>3<\/em>, 694.<\/li><li>T. Phoeung <em>et al.<\/em>, <em>Chem. <\/em><em>Mater.<\/em> <strong>2017<\/strong>, <em>29<\/em>, 10418.<\/li><li>P. Schaaf, J. B. Schlenoff, <em>Adv. <\/em><em>Mater.<\/em> <strong>2015<\/strong>, <em>27<\/em>, 2420.<\/li><li>J. K. Bediako, E. S. M. Mouele, Y. El Ouardi, E. Repo, <em>Chemical Engineering Journal<\/em> <strong>2023<\/strong>, <em>462<\/em>, 142322.<\/li><\/ol><p>\u00a0<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-394d362 elementor-widget elementor-widget-image\" data-id=\"394d362\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"664\" height=\"193\" src=\"https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2025\/08\/Schema-ProPad.jpg\" class=\"attachment-medium_large size-medium_large wp-image-1285\" alt=\"\" srcset=\"https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2025\/08\/Schema-ProPad.jpg 664w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2025\/08\/Schema-ProPad-300x87.jpg 300w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2025\/08\/Schema-ProPad-344x100.jpg 344w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2025\/08\/Schema-ProPad-275x80.jpg 275w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2025\/08\/Schema-ProPad-394x115.jpg 394w\" sizes=\"auto, (max-width: 664px) 100vw, 664px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6773fbf elementor-widget elementor-widget-text-editor\" data-id=\"6773fbf\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p style=\"text-align: center;\"><em>Scheme of preparation of protein based materials from albumin, collagen and\/or chitosan and example of albumin-based biomaterial (optical and SEM image).<\/em><\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1fe7f88 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"1fe7f88\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-e32f74b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e32f74b\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-a997260\" data-id=\"a997260\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c5b41f7 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c5b41f7\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c07578d\" data-id=\"c07578d\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3900ecb elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3900ecb\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-9991f29\" data-id=\"9991f29\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-2d85e3b elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"2d85e3b\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-b093693\" data-id=\"b093693\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f299fa2 elementor-widget-divider--separator-type-pattern elementor-widget-divider--no-spacing elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"f299fa2\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\" style=\"--divider-pattern-url: url(&quot;data:image\/svg+xml,%3Csvg xmlns=&#039;http:\/\/www.w3.org\/2000\/svg&#039; preserveAspectRatio=&#039;none&#039; overflow=&#039;visible&#039; height=&#039;100%&#039; viewBox=&#039;0 0 24 24&#039; fill=&#039;black&#039; stroke=&#039;none&#039;%3E%3Cpath d=&#039;M24,8v12H0V8H24z M24,4v1H0V4H24z&#039;\/%3E%3C\/svg%3E&quot;);\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-e2f7de4 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e2f7de4\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1d474c7\" data-id=\"1d474c7\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-cef0158 elementor-widget elementor-widget-heading\" data-id=\"cef0158\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\"><div class=\"wrap\" role=\"document\"><div class=\"content\"><div class=\"inner-container\"><section class=\"content-editor\"><div data-elementor-type=\"wp-page\" data-elementor-id=\"560\" class=\"elementor elementor-560 elementor-edit-area elementor-edit-mode elementor-edit-area-active\" data-elementor-title=\"Page\"><div class=\"elementor-section-wrap ui-sortable\"><section data-id=\"fc1b03e\" data-element_type=\"section\" data-model-cid=\"c3678\" class=\"elementor-element elementor-element-edit-mode elementor-element-fc1b03e elementor-section elementor-top-section elementor-section-boxed elementor-section-height-default\"><div class=\"elementor-container elementor-column-gap-default ui-sortable\"><div data-id=\"936a057\" data-element_type=\"column\" data-model-cid=\"c3679\" class=\"elementor-element elementor-element-edit-mode elementor-element-936a057 elementor-element--toggle-edit-tools elementor-column elementor-top-column ui-resizable\" data-col=\"100\"><div class=\"elementor-widget-wrap elementor-element-populated ui-sortable\"><div data-id=\"ae608cb\" data-element_type=\"widget\" data-model-cid=\"c3683\" class=\"elementor-element elementor-element-edit-mode elementor-element-ae608cb elementor-element--toggle-edit-tools elementor-widget elementor-widget-heading ui-resizable elementor-element-editable\" data-widget_type=\"heading.default\"><div class=\"elementor-widget-container\"><h2 class=\"elementor-heading-title elementor-size-default elementor-inline-editing pen\" data-elementor-setting-key=\"title\" contenteditable=\"true\" data-pen-placeholder=\"\u00c9crivez ici...\"><\/h2><h2 class=\"elementor-heading-title elementor-size-default elementor-inline-editing pen\" data-elementor-setting-key=\"title\" contenteditable=\"true\" data-pen-placeholder=\"\u00c9crivez ici...\">JOBS FILLED<\/h2><\/div><\/div><\/div><\/div><\/div><\/section><\/div><\/div><\/section><\/div><\/div><\/div><\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-62dfdfe elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"62dfdfe\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-a0bbf81\" data-id=\"a0bbf81\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-521735b elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"521735b\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-b010a73 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"b010a73\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-75032ab\" data-id=\"75032ab\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-3da6ad0 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3da6ad0\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-1b703ab\" data-id=\"1b703ab\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-cbcf363 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"cbcf363\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-3c3bbd7\" data-id=\"3c3bbd7\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-579077c elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"579077c\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-71759e8 elementor-widget elementor-widget-image\" data-id=\"71759e8\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"93\" src=\"https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-offre-these-300x93.png\" class=\"attachment-medium size-medium wp-image-940\" alt=\"\" srcset=\"https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-offre-these-300x93.png 300w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-offre-these-1024x319.png 1024w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-offre-these-768x239.png 768w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-offre-these-1536x478.png 1536w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-offre-these-2048x638.png 2048w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-offre-these-321x100.png 321w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-offre-these-257x80.png 257w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-offre-these-394x123.png 394w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-offre-these-915x285.png 915w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-offre-these-1240x386.png 1240w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-offre-these-1920x598.png 1920w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-727dcfa elementor-widget elementor-widget-heading\" data-id=\"727dcfa\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">THESIS OFFER<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e766e4d elementor-widget elementor-widget-text-editor\" data-id=\"e766e4d\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>In the U1121 laboratory, three priority thesis topics are available within the Doctoral School 182 \u00ab\u00a0Physics-Chemistry-Physics\u00a0\u00bb:<\/p><p>1. <strong><span style=\"color: #0000ff;\">Development of self-assembled protein systems for the delivery of anti-inflammatory molecules: application to the problem of osteoarthritis<\/span><\/strong> \/ B\u00e9atrice HEURTAULT<\/p><p>\u00a0<\/p><p>2. <span style=\"color: #3366ff;\"><strong>Hydrogels based on peptides and polysaccharides to manage chronic wounds<\/strong><\/span> \/ Philippe Lavalle<\/p><p>\u00a0<\/p><p>3. <strong><span style=\"color: #00ccff;\">Valvular mechanotransduction by serotonin and the 5-HT2B receptor in a static 2D and dynamic 3D environment<\/span><\/strong> \/ Dominique Vautier &amp; Laurent Monassier<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c3e3224 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"c3e3224\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/edpcp.u-strasbg.fr\/?page_id=7819\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-text\">Link ED 182<\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7e80862 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"7e80862\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-cbb6a8c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"cbb6a8c\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-2e8e9dd\" data-id=\"2e8e9dd\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-7b55003 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"7b55003\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-949a7dd\" data-id=\"949a7dd\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-c7b59f9 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c7b59f9\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-bb7421b\" data-id=\"bb7421b\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-edf7f64 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"edf7f64\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3d95b39 elementor-widget elementor-widget-image\" data-id=\"3d95b39\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"93\" src=\"https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-offre-these-300x93.png\" class=\"attachment-medium size-medium wp-image-940\" alt=\"\" srcset=\"https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-offre-these-300x93.png 300w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-offre-these-1024x319.png 1024w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-offre-these-768x239.png 768w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-offre-these-1536x478.png 1536w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-offre-these-2048x638.png 2048w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-offre-these-321x100.png 321w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-offre-these-257x80.png 257w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-offre-these-394x123.png 394w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-offre-these-915x285.png 915w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-offre-these-1240x386.png 1240w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-offre-these-1920x598.png 1920w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f976318 elementor-widget elementor-widget-heading\" data-id=\"f976318\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">THESIS OFFER: SMART ANTIMICROBIAL HYDROGELS BASED ON SELF-ASSEMBLIES OF PEPTIDES\u200b<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-221fd94 elementor-widget elementor-widget-text-editor\" data-id=\"221fd94\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>DIRECTEUR DE THESE : PHILIPPE LAVALLE<br \/>INSERM \/ CNRS \/ UNIVERSITE DE STRASBOURG, UMR_S 1121, BIOMATERIAUX ET BIOINGENIERIE, CRBS 1 RUE BOECKEL, 67000 STRASBOURG <br \/>TEL : 03 68 85 30 61 ; E-MAIL : philippe.lavalle@inserm.fr<\/p><p>The resurgence of antibiotic-resistant bacterial strains is becoming a major problem, especially in cases of nosocomial infections. More than 50% of these nosocomial infections are linked to medical devices such as implants, catheters, catheters, etc. Thus, there is an urgent need to develop new alternative strategies to conventional antibiotics and innovative antimicrobial materials. Moreover, chronic wounds, and more specifically diabetic wounds, are prone to infections and lead to major complications.<\/p><p>Our recent work on polypeptide-based coatings, including polyarginine (1-4), has shown the effectiveness of these molecules. However, at present, there is no specificity against only pathogenic bacteria and fungi. In this project, an entirely new family of smart antibacterial hydrogels. These hydrogels will provide antimicrobial activity exclusively in the presence of one specific microbial strains. The activity will based on the local production of antimicrobial peptides and in addition to their self-asembly ability forming locally a supramolecular network arounf the bacteria or fungi (5). It will result from the interaction of the peptides with the bacterial membrane and not to their action onto the bacterial metabolism as do conventional antibiotics. This will prevent bacterial resistance. Moreover, the peptide self-assembly will isolate the bacteria one from each other and thus will prevent biofilm formation and will facilitate their erradication. The specificity of the action will be obtained by tranforming precursor peptides into active self-assembling peptides through stimuli produce by a specific bacteria. The advantage of this specific activation of the targeted pathogens will be the preservation of the microbiota involved in many biological function. These innovative hydrogels will be a local alternative to systemic antibiotherapy. They will be used in many applications and could be incorporated in bandages or directly brought in contact with chronic wounds in a injectable form.&lt;br&gt;<br \/>This work will be performed at the Biomaterials and Bioengineering lab (https:\/\/www.biomaterials-bioengineering.com) in close collaboration with clinicians and medical device companies.<\/p><p>1. Lebaudy E., Petit L., Nomin\u00e9 Y., Heurtault B., Ben Hadj Kaddour I., Senger B., Rodon Fores J., Vrana N. E., Barbault F., Lavalle P., \u201cThe antibacterial properties of branched peptides based on poly(l-arginine): In vitro antibacterial evaluation and molecular dynamic simulations\u201d, Eur. J. Med. Chem., 2024, 268, 116224.<\/p><p>2. Knopf-Marques H., et al. \u00ab\u00a0Multifunctional polymeric implant coatings based on gelatin, hyaluronic acid derivative and chain length-controlled poly(arginine)\u201d, Mat. Sci. Engineer. C, 104, 109898, 2019.<\/p><p>3. Mutschler A., et al. \u00ab\u00a0Nature of the polyanion governs the antimicrobial properties of poly(arginine)\/polyanion multilayer films\u00a0\u00bb, Chem. Mater., 2017, 29, 3195.<br \/>4. Patent EP3962543B1 \u201cPolypeptide and hyaluronic acid coatings\u201d, Lavalle P., Calligaro C., Gribova V., Tallet L., Vrana E.<\/p><p>5. Muller C. et al. \u201cLocalized Enzyme-Assisted Self-Assembly of low molecular weight hydrogelators. Mechanism, applications and perspectives\u201c, Adv. Coll. Int. Sci, 2022, 102660.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b6516d6 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"b6516d6\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-d5ad9c9 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"d5ad9c9\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-4114708\" data-id=\"4114708\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-1aae202 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"1aae202\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-998a443\" data-id=\"998a443\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-697508f elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"697508f\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a934727 elementor-widget elementor-widget-image\" data-id=\"a934727\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"93\" src=\"https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-offre-these-300x93.png\" class=\"attachment-medium size-medium wp-image-940\" alt=\"\" srcset=\"https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-offre-these-300x93.png 300w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-offre-these-1024x319.png 1024w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-offre-these-768x239.png 768w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-offre-these-1536x478.png 1536w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-offre-these-2048x638.png 2048w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-offre-these-321x100.png 321w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-offre-these-257x80.png 257w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-offre-these-394x123.png 394w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-offre-these-915x285.png 915w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-offre-these-1240x386.png 1240w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-offre-these-1920x598.png 1920w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-886ad6f elementor-widget elementor-widget-heading\" data-id=\"886ad6f\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">THESIS OFFER: COMPACT PROTEIN-BASED MATERIALS AS TOUGH HYDROGELS FOR CARTILAGE AND TENDON REPAIR\u200b<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3dac025 elementor-widget elementor-widget-text-editor\" data-id=\"3dac025\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>DIRECTEUR DE THESE : ANDREAS REISCH<\/p><p>INSERM \/ CNRS \/ UNIVERSITE DE STRASBOURG, UMR_S 1121, BIOMATERIAUX ET BIOINGENIERIE, CRBS 1 RUE BOECKEL, 67000 STRASBOURG <br \/>TEL : 03 68 85 42 66 ; E-MAIL : reisch@unistra.fr<\/p><p>Hydrogels have proven to be valuable biomaterials for repair, regeneration and engineering of soft biological tissues. However, classical hydrogels are quite soft and fragile materials that fail in mimicking stiff yet elastic tissues like cartilage and tendon, stimulating an increasing interest in so-called tough hydrogels (1). Ideally, such biomaterials should, at first, close the defect and assure the cohesion of adjacent tissues, while limiting adverse reactions, and then, in the longer run, help in the repair of the tissue and the (re)establishment of normal functionality (2). Mechanical and adhesive properties therefore need to be combined with the presence of biological clues and controlled degradation.<\/p><p>Our lab has recently discovered a new approach to obtain mechanical resistant biomaterials composed only of albumin, through simple drying of protein solutions in the presence of certain salts, without any chemical crosslinking (3). The objective of the present PhD thesis will therefore be to extend this approach to the development of protein based tough hydrogel materials with mechanical properties close to those of cartilage and tendon, suitable for tissue-engineering applications. <br \/>In a first step, the formation of albumin based materials will be monitored using fluorescence microscopy and F\u00f6rster resonance energy transfer (FRET), IR spectroscopy, and mechanical tests. Modification of the surface chemistry of albumin will be used to link properties of constituents, assembly conditions and final properties. The results will be the basis to extend the approach to the incorporation of increasing concentrations of (i) other soluble proteins and peptides, notably fibrinogen, elastin like peptides, charged peptides and resilin. (ii) Different types of other biomacromolecules, notably charged polyscaccharides will be integrated. And (iii) fibrous proteins, notably collagens, will be included. In this way the spectrum of biochemical composition and mechanical properties will be largely extended, and elastic modulus and toughness will be increased. The obtained materials will then be evaluated with respect to their interaction and colonization with cells and their biodegradation profile. <br \/>The PhD project will result in a new family of all natural tough biomaterials produced in low-energy, waterborne processes with potential applications as structural biomaterials for cartilage and tendon repair and engineering.&lt;br&gt;<\/p><p>This work will be performed at the Biomaterials and Bioengineering lab (https:\/\/www.biomaterials-bioengineering.com) in close collaboration with clinicians and the start-up Albupad .<\/p><p>1. Petelin\u0161ek, N.; Mommer, S. Tough Hydrogels for Load-Bearing Applications. Adv. Sci. 2024, 11 (12), 2307404. https:\/\/doi.org\/10.1002\/advs.202307404.<br \/>2. Ullah, S.; Chen, X. Fabrication, Applications and Challenges of Natural Biomaterials in Tissue Engineering. Appl. Mater. Today 2020, 20, 100656. https:\/\/doi.org\/10.1016\/j.apmt.2020.100656.<br \/>3. Aloui, E.; De Giorgi, M.; Frisch, B.; Lavalle, P.; Schaaf, P. Protein Based Biomaterial with Viscoelastic Properties. EP 3811982 A1<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-849f39e elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"849f39e\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-ae7bb84 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"ae7bb84\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-52754df\" data-id=\"52754df\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-d76a10c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"d76a10c\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-84e4fa7\" data-id=\"84e4fa7\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ab99bfa elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"ab99bfa\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bd606b5 elementor-widget elementor-widget-image\" data-id=\"bd606b5\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"93\" src=\"https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-offre-these-300x93.png\" class=\"attachment-medium size-medium wp-image-940\" alt=\"\" srcset=\"https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-offre-these-300x93.png 300w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-offre-these-1024x319.png 1024w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-offre-these-768x239.png 768w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-offre-these-1536x478.png 1536w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-offre-these-2048x638.png 2048w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-offre-these-321x100.png 321w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-offre-these-257x80.png 257w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-offre-these-394x123.png 394w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-offre-these-915x285.png 915w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-offre-these-1240x386.png 1240w, https:\/\/us.biomaterials-bioengineering.com\/wp-content\/uploads\/2024\/10\/Logo-offre-these-1920x598.png 1920w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-047dec5 elementor-widget elementor-widget-heading\" data-id=\"047dec5\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">BIOLOGICAL AND CHEMICAL APPLICATIONS OF ELECTROPOLYMERIZED MATERIALS MADE FROM A MUSHROOM POLYPHENOL<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4435965 elementor-widget elementor-widget-text-editor\" data-id=\"4435965\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<p>DIRECTEUR DE THESE : VINCENT BALL<\/p><p>INSERM \/ CNRS \/ UNIVERSITE DE STRASBOURG, UMR_S 1121, BIOMATERIAUX ET BIOINGENIERIE, STRASBOURG <br \/>TEL : 03 88 14 70 62 ; E-MAIL : VBALL@UNISTRA.FR<\/p><p><br \/>The electrodeposition of films from polyphenol containing solutions allows to produce functional and homogenous coatings on conductive materials from natural molecules known to display a broad range of biological properties (1,2). In a previous PhD work performed at the INSERM 1121 Unit in Strasbourg, it has been shown that thick (up to 400 nm) and highly swollen films can be deposited on carbon and gold working electrodes from aqueous solutions of 1,8-dihydroxynaphtalene (1,8-DHN), a natural polyphenol from mushrooms. Those films display antioxidant activities and are antibacterial against several strains of Pseudomonas Aeroginuosa and can be transfered on polydimethylsiloxane sheets.<br \/>&lt;br&gt;It is the aim of the proposed PhD work to enlarge the applications of the 1,8-DHN based films and to investigate their structure. In particular their biocompatibility, the possibility to use them as biosensors and their electrical conductivity (without or with the incorporation of few layer graphene during the electrodeposition) will be investigated. Finally the electrocatalytic properties of the 1,8-DHN films incorporating metalic nanoparticles will also be studied.<\/p><p><br \/>1. Ball, V. (2017) Electrodeposition of pyrocatechol based films: influence of potential scan rate, pyrocatechol concentration and pH. Colloids and Surfaces A: Physicochem. &amp;amp; Eng. Aspects. 518, 109-115.<br \/>2. Ortiz-Pena, N, Ihiawakrim, D.; Ball, V.; Stanescu, S.; Rastei, M.; Sanchez, C.; Portehault, D.; Ersen. (2020) Correlative microscopy insight on electrodeposited ultrathin graphite oxide films. J. Phys. Chem. Lett. 11, 9117-9122.<\/p>\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-856f903 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"856f903\" data-element_type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-9db841c elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"9db841c\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5482c7d\" data-id=\"5482c7d\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>JOB OFFERS Polymer Nanoparticles loaded with Au Nanoclusters for NIR-II Bioimaging Luminescence and fluorescence have the potential to achieve fast and sensitive biosensing and bioimaging with resolutions down to single biomolecules, but they require powerful and specific probes. Luminescent polymer &hellip; <a href=\"https:\/\/us.biomaterials-bioengineering.com\/index.php\/job-offers\/\">Read More<\/a><\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":6,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"class_list":["post-560","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/us.biomaterials-bioengineering.com\/index.php\/wp-json\/wp\/v2\/pages\/560","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/us.biomaterials-bioengineering.com\/index.php\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/us.biomaterials-bioengineering.com\/index.php\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/us.biomaterials-bioengineering.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/us.biomaterials-bioengineering.com\/index.php\/wp-json\/wp\/v2\/comments?post=560"}],"version-history":[{"count":121,"href":"https:\/\/us.biomaterials-bioengineering.com\/index.php\/wp-json\/wp\/v2\/pages\/560\/revisions"}],"predecessor-version":[{"id":1297,"href":"https:\/\/us.biomaterials-bioengineering.com\/index.php\/wp-json\/wp\/v2\/pages\/560\/revisions\/1297"}],"wp:attachment":[{"href":"https:\/\/us.biomaterials-bioengineering.com\/index.php\/wp-json\/wp\/v2\/media?parent=560"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}